Lopo Vaz de Sampaio was an administrator of the Portuguese Empire. He was also the captain of Vasco da Gama, a famous Portuguese explorer. During 1528-29, Lopo Vaz de Sampaio seized the fort of Mahim from the Gujarat Sultanate, when the King was at war with Nizam-ul-mulk, the emperor of Chaul, a town south of Bombay.